The two neighborhoods with the largest concentrations of drinking establishments and clubs are Fells Point and Powerplant Live!. Other fine wining or boozing and dining neighborhoods include Canton Square, Mt. Vernon, Federal Hill, Hampden, and the Station North Arts and Entertainment District. Baltimore is also the home of the oldest Irish pub in the United States, Patrick's of Pratt Street, established in 1847.
Fells Point is the city's most popular district for both eating and drinking, it is located about a 15 min walk from downtown, or a short cab ride. Many bars in this area feature live music and most have excellent selections of Maryland and imported craft beers. The Full Moon Saloon on Aliceanna Street brings outstanding blues artists to the stage, while the Cat's Eye pub on Thames pronounced as it is spelled, not like the river in London has jazz and blues. Also be sure to visit Bertha's on Broadway, John Steven Ltd. on Thames, and Max's Taphouse for the widest beer and shooter selection plus Quiz-a-ma-jig trivia every Thursday night.
Max's on Broadway is Baltimore's veritable beer museum, with a long list of hard-to-find beers from around the world.
Powerplant Live! is an area just off of the Inner Harbor that has two blocks of nothing but bars, clubs and restaurants. It has an outdoor area that has music and other events during good weather. Drinks and food are low quality and overpriced since there is an unending stream of tourists unfamiliar with the city strolling in, but even the most hip Baltimore hipsters will find themselves here every now and then for the free live performances.
Brewer's Art on Charles St specializes in Belgian ales. Cross Street Market in bar-saturated Federal Hill has a fine sushi and raw bar, and an excellent happy hour on Friday.
National Bohemian affectionately known as 'Natty Boh' is the popular local cheap beer. They are generally no more than $2-3 anywhere in Baltimore, and most places serve them in cans.
Please note that all bars in Baltimore and the state of Maryland are completely non-smoking.